Prolixin

What you should know before using

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatrics

There is no specific information comparing use of buclizine, cyclizine, and meclizine in children with use in other age groups. However, children may be especially sensitive to the anticholinergic effects (e.g., dryness of mouth, nose, and throat) of these medicines.

Geriatric

There is no specific information comparing use of buclizine, cyclizine, and meclizine in the elderly with use in other age groups. Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. However, older people may be especially sensitive to the anticholinergic effects (e.g., constipation; difficult urination; dryness of mouth, nose, and throat) of these medicines.

These medicines have not been shown to cause birth defects or other problems in humans. However, studies in animals have shown that buclizine, cyclizine, and meclizine given in doses many times the usual human dose cause birth defects, such as cleft palate.

Breast Feeding

Although these medicines may pass into breast milk, they have not been reported to cause problems in nursing babies. However, since these medicines tend to decrease the secretions of the body, it is possible that the flow of breast milk may be reduced in some patients.

Drug Interactions

Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

• Arsenic Trioxide
• Bepridil
• Cisapride
• Dofetilide
• Droperidol
• Grepafloxacin
• Levomethadyl
• Mesoridazine
• Pimozide
• Sparfloxacin
• Terfenadine
• Thioridazine
• Venlafaxine
• Ziprasidone

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acecainide
• Ajmaline
• Amiodarone
• Amisulpride
• Amitriptyline
• Amoxapine
• Aprindine
• Arsenic Trioxide
• Astemizole
• Azimilide
• Bretylium
• Chloral Hydrate
• Chloroquine
• Chlorpromazine
• Clarithromycin
• Desipramine
• Dibenzepin
• Disopyramide
• Dofetilide
• Dolasetron
• Doxepin
• Droperidol
• Encainide
• Enflurane
• Erythromycin
• Fentanyl
• Flecainide
• Fluconazole
• Fluoxetine
• Foscarnet
• Gatifloxacin
• Gemifloxacin
• Halofantrine
• Haloperidol
• Halothane
• Hydroquinidine
• Ibutilide
• Imipramine
• Isoflurane
• Isradipine
• Levofloxacin
• Levomethadyl
• Levorphanol
• Lidoflazine
• Lithium
• Lorcainide
• Mefloquine
• Methadone
• Metrizamide
• Morphine
• Morphine Sulfate Liposome
• Moxifloxacin
• Nortriptyline
• Octreotide
• Oxycodone
• Paliperidone
• Pentamidine
• Pimozide
• Pirmenol
• Prajmaline
• Probucol
• Procainamide
• Procarbazine
• Prochlorperazine
• Propafenone
• Quetiapine
• Quinidine
• Risperidone
• Sematilide
• Sertindole
• Sotalol
• Spiramycin
• Sulfamethoxazole
• Sultopride
• Tedisamil
• Telithromycin
• Tramadol
• Trifluoperazine
• Trimethoprim
• Trimipramine
• Vasopressin
• Ziprasidone
• Zolmitriptan
• Zotepine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially:

• Asthma, bronchitis, emphysema, or other chronic lung disease—Cyclizine or meclizine may cause serious breathing problems in patients who have any of these conditions.

• Enlarged prostate or
• Glaucoma or
• Intestinal blockage or
• Urinary tract blockage—Buclizine, cyclizine, or meclizine may make these conditions worse.

• Heart failure—Cyclizine may make the condition worse.