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  I'm With You
  

  64ford (12/26/08)

  University of California Davis Cancer Center researchers have come across a way to block a cancer gene’s own repair mechanism and make chemotherapy more effective for kidney cancer patients. The findings, considered the first of its kind, are published in the Cancer Biology and Therapy report. “Cancer cells are notorious in their ability to rapidly create copies of themselves,” said Robert Weiss, a UC Davis professor of nephrology and chief of nephrology at the Sacramento Veterans’ Affairs Hospital. “While the latest medications slow down that process, they do not tend to be curative and have many side effects. We wanted to find ways to help make chemotherapeutics as effective as possible at the lowest doses possible.” New chemotherapy medications destabilize cancer cells at the DNA level, reducing their ability to replicate, Weiss said in a news release. He was aware that the p21 gene has a critical role in restoring cancer cell DNA and possibly circumventing the benefits of those treatments, so Weiss focused on identifying compounds that could interrupt the pathway. The team tested thousands of compounds and determined that 12 bind to the recombinant protein p21. Three of the compounds decreased p21 expression, blocking kidney cancer cells’ ability to recover and increase their responsiveness to treatments. “The results are very exciting, especially given how difficult kidney cancer has so far been to treat,” Weiss said. “Our work offers hope that in the future these p21 inhibitors can be refined and used in concert with other conventional as well as novel cancer treatments to increase the comfort and life spans of patients with kidney cancer.” Now, Weiss and his team will focus on three candidate compounds to determine the lowest concentrations that will remain effective and to optimize their anti-cancer properties. He will test those compounds with standard treatments in animal models and, if successful, later in human trials. “The goal is to find new approaches to treating a cancer for which few options currently exist and make those approaches available in clinical settings as quickly as possible,” he said. Other authors in the study are See-Hyoung Park, Xiaobing Wang, Riuwi Liu and Kit Lam. The research was supported by the National Cancer Institute, U.S. Department of Veterans’ Affairs, Morris Animal Foundation, National Institutes of Health and National Science Foundation.
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  Rainbow
  

  64ford (12/25/08)

  Joy to you and yours on this blessed day. Rudy B cancer fighter. Doing well this day God has Bless us all....
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  Santa
  

  joyciesgirl (12/24/08)

  Merry Christmas. Love Sherrie
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  Hug
  

  joyciesgirl (12/21/08)

  Thanks for your note of support. Things are getting easier. Love Sherrie
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  Hug
  

  Beccaanne (10/19/08)

  Hi Tiny 33, please know that my thoughts and prayers are with you too, how are you doing these days ?? I'm having alot of ups and downs lately, we are currently waiting for another surgery date, which should be the 10th of 17th of Nov... We have had nothing but road blocks with the cancer since Aug 1st and Tim is feeling good he just has fatigue, sometimes a little pain, not often and my fear is after the surgerty he may go downhill but we have to stay positive daily and just wait and see how he does....The way i have to look at things is that i am not in control of this and God is, please let me know how you are doing, i care, thanks so much for the hug, hope to talk soon.... Becca
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  Celebration
  

  Bellafelice (10/18/08)

  Dearesrt Tiny33-Thank you so very much for the lovely note and prayers...There definitely is Divine Intervention going on in our lives in cases like Bobs and in people as wonderful as you are!!! Massive gratitude for being there for us and I want to do the same for you too!! Sincerely-Marilyn-Happiest day of our life here in Toledo
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  Flowers
  

  Bellafelice (10/18/08)

  Thank you sooo much-we had great incredbile news-The surgeon got it all and it was a Stage 1 B and also was a grade 2-that is very unlikely to ever reoccur-massive love and thanks-we were very fortunate...Love marilyn and Bob in Toledo
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  Hug
  

  Beccaanne (10/07/08)

  That scripture is so true, thanks Sherrie for sending it to me, it helps to know that we are all in this this togeather and togeather we fight much harder, as a group of people suffering with mrcc in our lives... Love, Becca
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  I'm With You
  

  joyciesgirl (10/05/08)

  Ecclesiastes 4:9, Two people are better than one,for they can help each other succeed. I am praying for your success Love, Sherrie
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  I'm With You
  

  Beccaanne (09/26/08)

  Keep up the good work yourself, i look at everyday as a new day,with Tim, life is so good today, even tho we are going thru the hardest thing, that we will probably ever go thru, it's ok... With people like you and this site, i don't know what i would of done without it, i thank God everyday, to give the strengh to not to be araid to write my feelings and thoughts and get help for myself, i would never of been able to talk about this cancer with him without you all, thanks so much for the hug, all my love and good wishes for you Tiny33, keep up the faith and i will to.... Becca Anne

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