What is Multiple Sclerosis MS
Multiple sclerosis (MS) is a chronic disease which affects the brain and spinal cord. MS can cause a variety of symptoms, including changes in sensation, visual problems, muscle we...
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Multiple sclerosis (MS) is a chronic disease which affects the brain and spinal cord. MS can cause a variety of symptoms, including changes in sensation, visual problems, muscle we...

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B12-Synthesis of myelin sheath
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Many people with MS seem to have Lack of B12 and Vit D. This blog is to look into the lack of B12.
http://www.healthline.com/adamcont... This link states that a metabolic problem of lack of Vit B12 can cause nerve damage. --------- TEST The BEST indicator or B12 deficiency is to ask your doctor to run a test to find out what your MMA (mehylmalonic Acid) levels are. If they are elevated you most probably have lack of B12. B12 What it does: Vitamin B12 works WITH folic acid in many body processes including SYNTHESIS of DNA, red blood cells and the insulation sheath (the myelin sheath) that surrounds nerve cells and facilitates the conduction of signals in the nervous system. Severe depletion manifests as pernicious anemia, which was invariably fatal until the discovery of B12 in liver. But long before anemia sets in, other conditions may manifest, most often neurological problems (numbness, pins and needles sensations, a burning feeling in the feet, shaking, muscle fatigue, sleep disorders, memory loss, irrational anger, impaired mental function and Alzheimer’s) or psychological conditions (dementia, depression, psychosis and obsessive-compulsive behavior). B12 HELPS 1.)Produce melatonin which HELPS you sleep 2.)Useful adjunct for diabetics 3.)Have been helpful for those with Asthma(sulfite sensitivity), eczema, psorsis, osteporosis, Lupus and MS. 4.)Plus Low B12 resutls in Low antibody response, impaired immunity and increaese in infections (MS viral/bacteria cause??) B12 & MS One condition that would seem obviously correlated with B12 deficiency is multiple sclerosis (MS), a disease characterized by demyelination of the central nervous system. Yet many studies indicate that those with MS have normal blood levels of the vitamin. Japanese researchers have found that in MS patients, there is a decrease in the binding capacity of B12, thus inhibiting the transport of B12 into the cells, even in patients with normal levels in their blood. Even so, they were able to achieve some improvement with high-dose supplementation. The benefit of B12 for depression may be due to B12’s ability to activate a substance called tetrahydrobiopterin (BH4), a compound which in turn helps activate "feel good" neurotransmitters like serotonin and DOPAmine. How to GET More B12 + Stop the loss of B12 1.) Eat Liver or shellfish (High in B12). Steak is good but get it on the rarer side as it preserves more of the B12. 2.) Eat Calcium such as Unpasteurized proteins help B12 absorbtion so does Bone broths that heal intestinal inflam. and increase absorption. 3.) Take coconut oil and consume lacto-fermented foods: these help fight against pathogens such as helicobacter pylori, which is associated with B12 deficiency. Eradication of the organism often clears up B12 deficiency. AVOID 1.)AVOID OVERconsumption of foods that BLOCK vitamin B12 intake or increase the body’s need for the vitamin, such as SOY foods and spirulina. 2.)Antacids and drugs that lower stomach acid levels: acid-suppressing drugs such as Tagamet, Zantac and Losec can lead to serious B12 deficiency 3.) Foods fortified with folic acid. Taking folic acid withOUT B12 can mask signs of B12 deficiency in red blood cells but will not protect against deficiencies in the nervous system. Folic acid and B12 WORK WELL TOGETHER and any supplementation program should include BOTH of these nutrients (Institute of Medicine.National Academy Press. Washington, DC 1998). 4.)Avoid taking EXCESS vitamin C(normal amount fine), especially for long periods. The ability of vitamin C to destroy B12 has been observed by several researchers--although this is disputed by others. Small amounts of natural vitamin C are a better choice than large amounts of synthetic vitamin C. 5.) Avoid smoking, vaccinations containing thimerosol (ie flue shot) that contain mercury & oral contraception which all deplete B12 6.) Avoid mycotoxins made by molds that interfere with B12 functions. As well as pesticides and xenotoxins. Since vitamin B12 in supplements is produced in exactly the same way as B12 in nature, that is, by bacterial fermentation, the danger of high doses in most cases is negligible. More Info on Vit B12 found below: http://www.westonaprice.org/basicn... Posted on 05/07/08, 10:05 am |
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HOLLY CRAP!!!
Per the Univ of Utah Physiology Dept, Estriol is a "BINDING protein REQUIRED for B12 ABSORPTION"!! This THEORY is encompassing many other theory's like hormones being related and WHY estriol is working is some people!!! ---- after the first trimester, the placenta makes estriol and progesterone. .... Binding protein required for vitamin B12 absorption (in terminal ileum) ... umed.med.utah.edu/usmle/PDA/Physio...
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Note to anyone reading this. Be patient and keep reading until you get to hormones way down list.
So estriol is only made during pregnancy, which would support the idea that Vit D levels are high for pregnant women. Is there any data to support the idea that MS lessens during pregnancy? I had twins before I knew I had it, and I was fatigued for at least 7 months--not necessarily MS.
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Per Jeffery Dach MD.
B12 deficiency ITSELF causes damage to the myelin sheath add this to stress hormones or "cold/flu" agents in your body causes even more damage. MAYBE depending on the absorption issue you are getting a little to almost none..... MAYBE difference between RRMS -> PPMS different absorption problems. Those with RR are getting some B12 to keep them going while PP getting basically nothing so even on its own the body is destroying itself from lack of B12. This is getting interesting!
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MMA looks to be a URINE TEST ..yes no poking Larry. Are you going to get one?
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From what I have read on B12, there are signs of malabsorption. What would you see as signs one might be deficient? I don't think I am, and won't be going to a doc until later in summer. I have just started a 1500 mcg supplement, and am making dietary changes.
Another question: from your last reference I could not see another source of estriol than placenta. Is there?
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Some people may be helped with estriol but DIFFERENT people may have problems with Different part of the absorption chain. Any break in ths chain keeps you from USING B12 to repair myelin.
You know this is NOT so far fetched. Osteoporosis is caused by not enough calcium..even if you take the calcium then you still need phosphorus, Vit D, etc or it won't work. The day you break your first bone is NOT when the problem started...it started years earlier but the system(bone here) breaks down. The difference is MS MAY possibly be an absorption of the B12. If you can't break it down into coenzyes after being absorbed then you could take these coenzymes directly. It baypasses B12 and goes to what you need directly. If you are on antacids and glucophage..look at other alternatives that will allow you to absorb B12 or shot directly into the bloodstream may bypass the absorption issue you have and allow for the repair of the myelin. Ask for a MMA urine test Della. If it comes back elevated then you probably have a B12 def. You can look into taking a coenzyme directly (look at the methyl one I posted in original message). CONSULT a nutritionist about what would be best for you.
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Ya Larry I think you are missing this thing, it does not matter how much is in your blood, it is the absorption.
2. The LDN probably has the body healing the guts(celiac is one of the conditions). 5 years on the LDN is a long time for healing stuff. I think this is the bomb.
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You know with the Penn State Univ finding that LDN showed 89% improvement in Crohns disease (autoimmune disease that as lump said affect your guts) that is very POSSIBLE.
Thank you for this VERY Constructive feedback. -- This is what we need here. I have heard now that several people don't want to post because of NON constructive feedback in other posts. PLEASE DO post information you have.. My point in this blog is to find the TRUTH, WHATEVER that may be. IF this theory is not correct I don't want to keep wasting my time with it. HOWEVER, IF this is correct it would benefit us all. PLEASE lets continue this discussion without the fear of being beat up.
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That's right, and I used to get piss tested about every week at work , it does not hurt, honest.
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For the railroad, I guess.
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