Hepatitis C is a blood-borne viral disease which can cause liver inflammation, fibrosis, cirrhosis and liver cancer. The hepatitis C virus (HCV) is spread by blood-to-blood contact...
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Pegasys vs Peg-Intron
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Someone asked this question on a previous discussion:
1) The two types of pegylated interferon approved for use in Hep C are Pegasys (Pegylated interferon alfa-2a which is made by Roche) and Peginterferon alfa-2b (Peg-Intron made by Schering Plough 2) Although the two forms of pegylated interferon differ in their pharmacokinetics it is not clear that these differences have important clinical implications. 3) NO LARGE TRIALS HAVE DIRECTLY COMPARED the two forms of pegylated interferon as monotherapy OR in combination with ribavirin 4) One such trial (the "Ideal study") is ongoing (http://www.idealstudy.com/). 5) The response rates in individual trials evaluating the two forms of pegylated interferon alone or in combination with ribavirin have been SIMILAR when comparable doses of the drugs have been used according to the dosing recommendations contained in the package insert. 6) Given there are no head to head trials of the two it is difficult to conclude that the side effect profile of the two pegylated interferons varies significantly. Hope this helps Dr O. Posted on 11/13/07, 07:11 pm |
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Hey Miss Doctor "O" I have done both of those and my last 3rd round of TX was everyday injections, Now I happen to have the box right in front of me so my dumb/ass wont miss typing this wrong, This was made by Inter/Mune
Infergen-Interferon alfacon-1 "A recombinant consensus alpha interferon derived from E.Coli. Have you ever heard anything about this? I did this injection "EVERY-NIGHT" No fun at all. This is one of them things I was tellin you about my blood cell count problems on an private e-mail message sister. But all of them caused several new health issuse for me. So you can understand, When I cop an attitude theses days about health care. Hey thanks for your info It helps us all. 
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Thanks Doc. Im on the pegasys and copegus for 47 more weeks. I had my first shot last Friday. Thanks for posting doc.
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Hey Tattman!
What you are on (Infergen) is NOT a pegylated interferon (the 2 pegylated inteferons used for Hep C are listed above) but rather a standard interferon which is WHY you have to use if 3-4 times a week instead of weekly. What does this mean? Remember pegylated interferons were an exciting advancement in the treatment of Hep C BECAUSE the attachment of polyethylene glycol to a protein (pegylation) reduces its rate of absorption following subcutaneous injection, reduces renal and cellular clearance, and decreases the immunogenicity of the protein. IMPORTANT POINT: All of these effects tend to enhance the half-life of the pegylated versus the native protein (so you can do once a week injections and side effect profile is better) Hope that helps: Dr O.
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Thank you Doc!! But when my first TX in 2001 was the pegasys interferron as well,and My Second TX was # 2 of what you were discribing too. But those first 2 treatments were only 1 shot a week. Its that last TX was everyday. Thankd for clearing that up Doc. Thank you!!
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bump..
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