Encephalitis is an acute inflammation of the brain, commonly caused by a viral infection. Sometimes, encephalitis can result from a bacterial infection, such as bacterial meningitis, or it may be a complication of other infectious diseases like rabies (viral) or syphilis (bacterial). Certain parasitic protozoal infestations, like by toxoplasma, can also cause encephalitis in people with compromised immune systems. Brain damage occurs as the inflamed brain pushes against the skull, and, depending on its severity, can lead to death.
Patients with encephalitis suffer from fever, headache, vomiting, confusion, drowsiness and photophobia. The patients could also suffer from weakness, seizure, and less commonly, stiffness of the neck. Rarely, the patients may have limb stiffness, slowness in movement and clumsiness, depending on the specific part of the brain involved. The symptoms of encephalitis are caused by the brain's defense mechanisms activating to get rid of the infection, including swelling, small bleedings and cell death.
Treatment is usually symptomatic. Reliably tested specific antiviral agents are available only for a few viral agents (e.g. aciclovir for herpes encephalitis) and are used with limited success for most infection except herpes simplex encephalitis. In patients who are very sick, supportive treatment, such as mechanical ventilation, is equally important.